August 17, 2022

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VGI Health Technology Limited (NSX:VTL) June 2022 Quarterly

Sydney, Australia, July 29, 2022 – (ABN Newswire) – The Administrators of VGI Health Technology Constrained (NSX:VTL) are happy to provide the pursuing update for the quarter ending 30 June 2022.

Position of Patent Ownership

On 4 April 2022, VGI Overall health Engineering Confined was delighted to announce that the the United States Patent and Trademarks Office (USPTO) intends to grant a divisional patent for the ‘Transmucosal Delivery of Tocotrienols’ to its wholly-owned subsidiary Invictus Biotechnology Pty Ltd. Earlier, a US patent directed to a approach of dealing with article exercising muscle mass soreness or delayed onset muscle soreness (DOMS) by transmucosal administration of a tocotrienol was granted in June 2020. The existing divisional patent software extends this coverage to pharmaceutical compositions made up of delta tocotrienol which have been formulated for transmucosal supply. This composition can be made use of for the procedure or prevention of additional indications these as fibrosis and cancer. The moment granted, the patent formally entitled ‘Transmucosal Delivery of Tocotrienol’ will present industrial rights in the US until finally 13 November 2032.

Technological and Solution Growth

On 21 March 2022, VGI Health was delighted to announce that Dr Jordan Moon, a member of its Scientific Advisory Board, will be presenting an abstract at the American Culture for Nutrition (ASN) Once-a-year Meeting, Nourishment 2022. In affiliation with the ASN, an abstract will be introduced during the meeting (14-16 June 2022) titled “Transmucosal delivery of tocotrienols from a delta-tocotrienol powder: A Multidose Pharmacokinetic research”. The abstract describes some of the benefits that have been produced from a pharmacokinetics research executed by Dr Moon in the US utilizing new formulations designed for the transmucosal supply of tocotrienols. These new formulations and solutions of manufacture are also the subject of a new patent submitting “PCT/AU2021/051449 – Transmucosal shipping of tocotrienols” produced by VTL’s whollyowned subsidiary Invictus Biotechnology Pty Ltd on 3 December 2021. The information from this research supports the truth that there is much more overall flexibility with dosages for this distinct drug shipping and delivery system than before study information experienced recommended.

Sixteen balanced investigate topics (m=8, f=8, 32 +/- 8 yrs, 171 +/- 7 cm, 81.6 +/- 13.8 kg) have been randomly administered possibly 40mg or 80mg of a delta tocotrienol (DT3) that contains powder in a fasted condition. Topics were asked to keep the powder less than their tongue right until it was fully dissolved.

Blood samples have been taken at , 60, 90, 120, 180, 240, 360, and 480 minutes. Subjects had been provided a meal consisting of carbs, proteins, and fats just after 4 hours. DT3 concentrations were being calculated from blood plasma utilizing protein precipitation followed by liquid-liquid extraction.

Analytes ended up separated by Liquid Chromatography Mass Spectrometry (LCMS) with the extracts assayed towards a calibration curve. DT3 bioavailability was assessed employing the parameters peak plasma concentration (Cmax), time to achieve peak plasma concentration (Tmax) and complete area below the plasma focus-time curve (AUC).

The plasma focus of DT3 arrived at 44.05 ng/ml (Cmax) for the 40mg team and reached 127.4 ng/ml (Cmax) (+83.4 ng/ml enhance) for the 80mg group. Tmax was accomplished at 360 minutes for the two the 40 and 80mg team. AUC for 40mg resulted in 9,941.6 ng/ml*min, with a +2.9 periods raise noticed in the 80mg team (29,072.2 ng/ml*min) as opposed to 40mg.

Transmucosal delivery of tocotrienols from a delta-tocotrienol powder containing 40mg and 80mg of DT3 resulted in a progressively elevated absorption amount for equally doses with 80mg appearing to improve full plasma DT3 by a big difference of +2.9 occasions that of a 40mg dose. Both equally 40 and 80mg doses of DT3 administered by way of transmucosal delivery have demonstrated increased plasma DT3 concentrations in wholesome males and women of all ages more than a period of time of no significantly less than 8 hrs.

About VGI Health Technology Confined:

VGI Overall health Engineering Constrained (NSX:VTL) is an Australian general public outlined biotechnology company creating and commercialising novel dietary health supplements and prescription medications primarily based on pure merchandise (tocotrienols) which have broad therapeutic possible, like: Delayed Onset Muscle mass Soreness, muscle mass recovery, physical exercise stamina, Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic SteatoHepatitis (NASH), pancreatic most cancers, hyperlipidaemia, hypertension and diabetes. VTL owns and controls patent and other mental property legal rights for novel approaches to non-invasively providing tocotrienols immediately to the target tissues. The Organization has a products advancement application for evidence-centered nutraceuticals and a scientific improvement program for prescription medications.

Speak to:

Glenn TongCEO and Taking care of Director
Ph: +61 () 412 193 350

Andrew CriminalTrader and Media Relations
Ph:+61 () 419 788 431

Catriona GloverEnterprise Secretary
Tel: +61 () 402 328 200

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